The African buffalo is very territorial and protective and is probably the most dangerous animal of the big five to humans. If this cow-like animal feels threatened it can become very aggressive and charge with astonishing speed. Buffaloes are mostly found in groups and large herds and spend a lot of their time grazing. Both male and female buffaloes have horns, but the males' horns curve and come together in the center, forming a big bony plate called a boss.

The primary predator of the buffalo is the lion. A buffalo will try to protect and rescue another member of the herd and they have even been seen killing a lion after the lion had killed a member of the group. Although the African buffalo and water buffalo resemble each other, they are not closely related.